Fatty Acid Synthesis during Early Linoleic Acid Deficiency in the Mouse.

The capacity of liver to synthesize long-chain fatty acids is greatly enhanced during early linoleate deficiency in mice. The enzymes catalyzing the synthesis of fatty acids from acetate or malonyl CoA were measured directly in soluble fractions isolated from fiver. The period of dietary restriction of linoleate is also accompanied by a rapid fall in the relative linoleate content of the liver; by marked changes in the composition of the fatty acids in liver; and by an accumulation of liver triglyceride.